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Smallpox is a highly contagious disease that is caused by a virus. It infected many human beings for thousands of years and led to uncountable deaths. The symptoms of this infection are severe and cause extreme discomfort to the affected person. There is still no cure available for smallpox, but after the advent of its vaccine, it had been eradicated worldwide by the year 1980. Some samples of smallpox have only been reserved for research purposes.