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Gangrene refers to the death of tissues of your body due to a lack of adequate blood supply or a serious bacterial infection. In majority of the cases, gangrene occurs in regions farthest from your heart, such as toes and fingers. However, it can also affect other body parts, including internal organs such as the gall bladder. Gangrene is considered a medical emergency and should be treated as soon as possible. Lack of treatment or delay can spread gangrene to the entire limb, in which the affected limb will have to be amputated. In severe cases, it can progress to a septic shock, leading to death.