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Kernicterus refers to brain damage that occurs due to high levels of bilirubin in the blood. Bilirubin is a waste product produced by your liver after the breakdown of red blood cells. In most newborn babies, bilirubin levels are usually high, resulting in newborn jaundice. Kernicterus, on the other hand, is a serious condition because, in this case, the bilirubin levels are high enough to cause brain damage. If hyperbilirubinemia (a high level of bilirubin) is noticed in a newborn baby, it is monitored closely to prevent its progression to kernicterus.