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Peptic Ulcer Disease (PUD) is a discontinuity or break in the stomach's inner lining, a protective layer in the stomach, composed of mucus and bicarbonate that neutralizes the stomach’s acid secreted by the stomach mucosa. Peptic ulcers are common in the first part of the small intestine, or sometimes the lower esophagus. The most common symptoms are burning sensation and pain in the stomach region. It is diagnosed by endoscopy and urease breath tests, and it is treated by medications and some surgical procedures when needed.