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Addison’s disease, also called hypocortisolism or adrenal insufficiency, occurs when the body is not producing adequate cortisol and sometimes aldosterone. Cortisol is produced by the adrenal glands, also known as the suprarenal gland, situated over the kidneys. The proper functioning of those tiny triangle-shaped glands is essential and controlled by higher centers in the brain. The adrenal gland is the endocrine gland, and it releases hormones in the blood. In Addison’s disease, the outer part of the adrenal gland, called the cortex, is damaged, failing Cortisol, aldosterone, androgens, and estrogen production. Some of the vital functions of cortisol are it helps control blood sugar levels, decreases inflammation after cellular injury, and assists in metabolism and memory control. Cortisol is also called a stress hormone and is actively released when there is any stress, flight, or fight situation in the body. For example, When the body is under stress, the hypothalamus, the high center of the brain, signals to the pituitary gland, which then enables the adrenal cortex to secret cortisol in the bloodstream, which increases the heart rate, activates the glucose production to be used by the active muscles, etc. and deactivates the other mechanisms of the body which are not needed in that immediate situation. Addison's disease, in its initial course, is unnoticed. It’s only alarming when the symptoms worsen and need immediate attention and a management plan.