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Amyloidosis is a group of disorders characterized by the accumulation of an insoluble protein called amyloid fibrils in various body organs, interfering with their normal function. The organs involved are the heart, liver, spleen, kidneys, nervous system, and digestive tract. Due to the involvement of various organs, the symptoms are often vague and take some time before the diagnosis is made. Some key features may be the presence of proteins in the urine, non-specific organ enlargement, and nervous system (peripheral nerves) disorders. There are many types of amyloidosis caused by genetic and environmental factors. Biopsy of the tissue involved can lead to a precise diagnosis. It is treated by removing the underlying cause and using certain medications for specific types directed at decreasing the production of amyloid fibrils.