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Zollinger-Ellison syndrome is a rare digestive disorder that results in excessive formation of the hormone gastrin. This hormone is released from our stomach normally to aid in digestion. Excessive production of gastrin can increase the release of gastric acid from your stomach, which in turn can cause ulceration of the digestive tract. In this condition, one or more tumors form in your pancreas or the initial part of your small intestine. These tumors, called gastrinomas, produce accessory gastrin. Certain medications and treatment options can manage Zollinger-Ellison syndrome.