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Chronic fatigue syndrome is a complex condition in which you always feel exhausted without any apparent medical reason. It is also known as myalgic encephalomyelitis or systemic exertional intolerance disease. It can last from six weeks to a few months or longer. This condition can worsen with mental or physical activity but does not seem to improve with complete rest. It is difficult to determine a single cause of this disease because it may occur due to a combination of different factors. Treatment is focused on relieving symptoms.