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FIP1L1-PDGFRA Gene Mutation FISH (Chronic Eosinophilic Leukemia)

Test Name

FIP1L1-PDGFRA Gene Mutation FISH (Chronic Eosinophilic Leukemia)

Also known as

Symptoms | Disorders | Treatments

About test

Mutations in the FIP1L1-PDGFRA gene may be useful in the diagnosis of a subset of chronic eosinophilic leukemias, termed hypereosinophliic syndrome (HES). Patients with HES have shown favorable response to tyrosine kinase inhibitor therapy, imatinib. FIP1L1-PDGFRA is also present in a subset of patients with systemic mastocytosis and these patients may respond to imatinib. In both HES and systemic mastocytosis, testing for FIP1L1-PDGFRA may be used for disease monitoring of patients on tyrosine kinase inhibitor therapy.

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