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Hypercalcemia is a condition in which your blood calcium level is abnormally high. Too much calcium in your blood can weaken your bones, cause kidney stones, and disrupt the functioning of your heart and brain. Overactive parathyroid glands are the most common cause of hypercalcemia. These four small glands are located near the thyroid gland in the neck. Cancer, certain other medical diseases, some medications, and taking too much calcium and vitamin D supplements are all possible causes of hypercalcemia. Hypercalcemia has a wide range of signs and symptoms, from none to severe. Treatment is determined by the underlying cause.