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Primary biliary cholangitis (PBC) is an autoimmune disease that affects the liver. The old name of this disease is primary biliary cirrhosis. Inside your liver are small bile ducts that carry and transfer a digestive substance called bile. In this disease, these bile ducts are inflamed and damaged, resulting in the buildup of bile in the liver causing liver cirrhosis. The liver loses its ability to execute its functions, resulting in the symptoms of tiredness, loss of appetite, itchiness, nausea, vomiting, and unexplained weight loss. With the progression of the disease, symptoms may include jaundice, easy bruising, swelling in the lower legs, and building of fluid in the abdomen. PBC is a slowly progressive long-term illness.