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Scleroderma is a connective tissue disorder that is characterized by hardening and induration of skin. Scleroderma itself is a manifestation of systemic sclerosis, an autoimmune disease involving skin, subcutaneous tissue, muscles, and bones. There is excessive deposition of connective tissue macromolecules in the skin that causes thickening. It is not an inherited disease, but genetic factors play an essential role in disease onset and progression.