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Hemochromatosis (also called iron overload) is the condition in which excess iron is accumulated in various organs of the body resulting in the dysfunction of the organs. The most common organs affected are the liver, heart, pancreas, pituitary, joints, and skin. The most important causes include hereditary hemochromatosis and iron overload due to repetitive transfusion of blood products for other disorders likethalassemia. Symptoms appear in middle age, with hepatic fibrosis being the first sequelae, followed by heart disease, joint pains, and diabetes. This disease causes severe organ complications; hence early diagnosis and treatment are crucial.