Uric acid is made as a by product when purine is broken down. Purines refer to nitrogen containing compounds that are present in the cells of the body, including the
This test used to measure the amount of uric acid found in the blood or the urine. When cells get older and die, they break down and release purine into the blood. To a minimal degree, purines are found in the body after the digestion of certain foods like liver, dried beans, peas, beer, anchovies and mackerel. Uric acid is largely removed from the body by the kidneys. It is eliminated from the body in the form of urine, with the remainder being ejected via stool. If there is too much uric acid in the body, it can accumulate in the body, leading to elevated levels in the blood, a condition known as hyperuricemia.
An excess of uric acid in the blood can lead to gout, a condition that involves the inflammation of joints because of the formation of uric acid crystals in the joint fluid. An excess of uric acid may also be deposited in the kidney, leading to kidney stones or kidney dysfunction. The accumulation of too much uric acid in the body can be due to either the production of excess uric acid, the poor elimination of uric acid or a combination of both conditions. High levels of uric acid tend to occur because there is a high level of cell death, which occurs due to some cancer therapies, or in some rare cases, has a tendency to make too much uric acid. The decreased elimination of uric acid occurs due to impaired kidney function because of kidney disease.