You have a pair of kidneys in your body, that make urine, which takes away unwanted waste materials from the body. Normally, the urine contains only a little amount of proteins, up to 150mg/day. Due to some malfunctioning, excess proteins are excreted in the urine, known as proteinuria. Proteins are not only the building blocks for our body but are also essential to maintain body fluid, fight infections, and are supposed to remain in the body for all the vital functions. Proteinuria results in the loss of proteins causing fluid retention, foamy urine, tiredness, etc.
Your kidneys contain several tufts of small blood vessels called glomeruli. As your blood flows through the kidneys, the glomeruli sieve it, extracting what your body requires from what it does not. If some protein is left in the urine, there are special reabsorbing tubules in the kidneys that re-absorb the important substances, including protein. Conditions affecting this procedure at either step are responsible for proteinuria.
Mostly, proteinuria is caused by minor medical conditions like dehydration, inflammation, intense physical activity, severe emotional or physical stress, or excessive intake of fluids. Sometimes, proteinuria can be an early indication of kidney disease. Some of the conditions affecting kidneys are;
In the US population, proteinuria was found to be 9.1% in females and 6.1% in males. Albuminuria was found to be 28.8% prevalent in diabetic patients and 16.0% in hypertensive patients. The starting age for proteinuria is 40 years. It is more prevalent in males than in females. It is found more in non-Hispanic blacks and Mexican Americans.
Having some conditions can increase your chances of having proteinuria;
Initially, proteinuria does not exhibit itself prominently. It is often found incidentally on routine blood tests. However, if the condition stays for a long duration, you may have the following signs and symptoms;
Diagnosis of proteinuria is usually made by checking proteins in the urine. A patient is asked to submit a sample of urine in a bottle or a jar which is then tested in the lab or at the doctor's office for the presence of proteins, especially albumin, by inserting a dipstick, which is a piece of chemically processed material, into the urine. If protein is present in the urine, the dipstick turns color. This test is called a dipstick urine test. Albumin excretion rate between 30 to 300 mg/day is labeled as moderately increased albuminuria, while levels greater than 300 mg/day are categorized as severely increased albuminuria. If urine is found to have proteins after three successive tests performed three months apart, your doctor may suspect kidney disease, and you may be advised to undergo a few investigations, like;
Other disorders that may need to be evaluated include;
Treatment of proteinuria requires eliminating the root cause, controlling the symptoms with medications, and halting the progression towards end-stage kidney disease.
The outlook for proteinuria is usually favorable if timely care is given, but it varies depending on the actual reason and the patient's age.
Without therapy, it has an extremely poor prognosis, especially if the kidney disease progresses quickly, leading to abrupt kidney problems in a matter of months. Malnutrition can come from the depletion of too much protein. Weight loss can occur as a result of this, which can be concealed by edema. Anemia and vitamin D deficiency are further complications of end-stage kidney disease.
Ultimately, the kidneys lose their function and accumulate harmful products that need to be removed immediately using dialysis. Dialysis is an unnatural method of eliminating excess liquids and toxins from your blood that is usually performed using a kidney dialysis machine.
If your kidney function deteriorates sufficiently, you may require a kidney transplant.
Certain factors linked with proteinuria are unavoidable. However, you may take measures to protect your kidneys.
Our clinical experts continually monitor the health and medical content posted on CURA4U, and we update our blogs and articles when new information becomes available. Last reviewed by Dr.Saad Zia on May 01, 2023.