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The liver is one of the most important organs of the body that plays a crucial role in digestion, detoxification, metabolism, and growth. It is located in the right upper quadrant of the abdomen and can be influenced by many different diseases that can be of shorter or longer duration. When the duration of the disease is more than six months, it is called chronic disease. So the chronic disease of the liver includes any disease which affects the liver for more than six months and results in the gradual destruction of the functional liver tissue, which is then replaced by fibrous non-functional tissue over the prolonged period of continuous injury. The liver loses its ability to execute its functions, resulting in loss of appetite, tiredness, weakness, nausea, vomiting, unexplained weight loss. With the progression of the disease, symptoms may include jaundice, itchiness, easy bruising, swelling in the lower legs, and building of fluid in the abdomen.
The agents and events leading to chronic liver disease may include viruses, parasites, chemicals, drugs, metabolic products, toxins, autoimmune diseases, and malformations.
Chronic liver disease is managed by correcting the underlying disorder, halting further damage, providing symptomatic relief, and offering palliative care and support.